Exercise: A brain changer in Parkinson’s disease

Exercise may help protect or even enhance the function of the neurones in Parkinsonian brains. Researchers have begun to show that engaging in structured, high‑intensity exercise can activate neuroplasticity and increase dopaminergic signalling in the brain. In trials, patients who carried out vigorous workouts—such as interval training or fast cycling—demonstrated improvements not only in motor symptoms but also in biomarkers of neuronal activity.

The article notes that exercise triggers beneficial molecular pathways, including improved mitochondrial function, reduced oxidative stress, and greater production of neurotrophic factors (which support neurone survival). These changes may help strengthen and preserve the functionality of dopamine-producing cells—the very cells compromised by Parkinson's disease.

Moreover, the piece emphasises that timing and consistency of exercise are crucial. Early initiation of an exercise regimen appears more effective, and sustained activity over months or years may yield the greatest neuroprotective effects. The commentary underscores that exercise is not just symptomatic therapy in Parkinson's disease—it has the potential to be disease modifying.