A new documentary on Peacock, "Matthew Perry: A Hollywood Tragedy", uncovers significant details surrounding the actor's passing at the age of 54.

Following the release of his autopsy report, which detected "high levels of ketamine" in his system after his death in 2023, the documentary claims that Perry was administered 27 doses of the drug within his final three days.

Former United States Attorney for the Central District of California, Martin Estrada, who led the investigation into Perry's death, stated, "Allegedly, Dr [Salvador] Plasencia provided ketamine to a live-in assistant who lacked medical training, and that assistant then administered it to Perry, despite his extreme risk factors."

Estrada further alleged that in mid-October, Plasencia ignored multiple warning signs but still complied with Perry's requests for injections.

"Dr Plasencia reportedly arranged various meeting locations with Mr Perry to supply ketamine," Estrada explained. "In one instance, they met in a Long Beach parking lot, where the drug was administered in the back of a car. Doctors are not supposed to inject patients in such conditions."

He continued, "As a trained medical professional, Dr Plasencia was fully aware of the risks. A central issue in our indictment is that every individual involved should have known better. They exploited a vulnerable person, prioritising their greed over Mr Perry's safety."

Despite witnessing an adverse reaction—where Perry reportedly "froze up"— Plasencia failed to take action, Estrada claimed.

"He allegedly continued to supply ketamine to Perry's assistant, who then administered it to the actor," he added.

According to the documentary, Perry's assistant, Kenneth Iwamasa, injected the final dose after the "Friends" star requested, "Shoot me up with a big one," unaware that it would be fatal. The ketamine was supplied by Jasveen Sangha, known as "The Ketamine Queen."

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Perry received the lethal dose either in or near his jacuzzi. Upon returning from errands, Iwamasa found him unresponsive in the water.

Retired Los Angeles Police Department detective Greg Kading stated that when Perry's demand for ketamine exceeded what Dr Plasencia and Dr Mark Chavez could provide, they turned to an intermediary.

Three of the five individuals charged in connection with Perry's death, including Iwamasa, Chavez, and another defendant, Fleming, have pleaded guilty.

Sangha, facing multiple charges, has denied the allegations against her through her attorney in a statement featured in the documentary.

Meanwhile, Plasencia has been charged with conspiracy to distribute ketamine, seven counts of ketamine distribution, and two counts of falsifying documents but has pleaded not guilty.