Williams only returned to competitive tennis in July following a 16-month absence from the sport.
The 45-year-old seven-time Grand Slam singles champion, playing this week for the first time in 16 months, had become the oldest woman to win a WTA match in more than two decades with Tuesday's first round win over Peyton Stearns.
The seven-times Grand Slam singles champion had not played a competitive match in 16 months, with her last appearance on the WTA Tour coming at the Miami Open in March last year.
The 43-year-old tennis icon was no match for her 26-year-old opponent, who was born just weeks before Williams played her first Grand Slam final at the US Open in 1997
Venus Williams insists she's not ready to call time on her career, claiming on Saturday she is probably the only player able to keep competing until she's 50.
Five-time Wimbledon singles champion Venus Williams has been awarded a wild card for next month's championships.
Two-time Australian Open champion Naomi Osaka became the latest star to pull out of the opening Grand Slam of the year Sunday, leaving the tournament deprived of some of the biggest names in the game.
The U.S. Open turned over Arthur Ashe Stadium to the Williams sisters on Thursday for a prime-time first round doubles match that could have been Serena's last after the pair fell 7-6 (5), 6-4 to the Czech duo of Lucie Hradecka and Linda Noskova.
American 15-year-old Cori Gauff stole the show on the opening day of Wimbledon with a debut victory over five-time champion and her inspiration Venus Williams.
Two-time Australian Open champion Naomi Osaka became the latest star to pull out of the opening Grand Slam of the year Sunday, leaving the tournament deprived of some of the biggest names in the game.
The U.S. Open turned over Arthur Ashe Stadium to the Williams sisters on Thursday for a prime-time first round doubles match that could have been Serena's last after the pair fell 7-6 (5), 6-4 to the Czech duo of Lucie Hradecka and Linda Noskova.
American 15-year-old Cori Gauff stole the show on the opening day of Wimbledon with a debut victory over five-time champion and her inspiration Venus Williams.
Serena Williams made her long-awaited comeback to tennis but the 23-time Grand Slam title winner and former world number one suffers defeat, playing alongside big sister Venus in a Fed Cup dead rubber.
Sloane Stephens stun two-times U.S. Open winner Venus Williams to ensure a new grand slam champion is crowned at the Flushing Meadows while Madison Keys hammer CoCo Vandeweghe to set up an all-American final.
Venus Williams vows to make amends for her Wimbledon final heartache by ending a bittersweet year on a high at the US Open.
Serena Williams may be missing from this year's French Open, but big sister Venus is still going strong and marks her Roland Garros 20th anniversary.
Maria Sharapova returns to tennis this week following her 15-month ban having tested positive for meldonium at the 2016 Australian Open.
Serena Williams clinched a record 23rd grand slam title at the Australian Open on Saturday but spent most of the immediate aftermath talking about her older sister Venus.
Serena Williams ended the fairytale run of Mirjana Lucic-Baroni at the Australian Open on Thursday with a crushing 6-2 6-1 win that set up a final against her sister Venus.
