Garbine Muguruza won her first Grand Slam title at the French Open on Saturday defeating top seed and defending champion Serena Williams in the final.

Twelve years younger than the American at 22, and playing in the first claycourt final of her career, the Venezuelan-born Spaniard upset the odds to win 7-5, 6-4.

She is the first Spanish woman to win a Grand Slam title since Arantxa Sanchez-Vicario in Paris in 1998 and she is the third straight first time Grand Slam winner after Flavia Pennetta at last year's US Open and Angelique Kerber at the Australian Open.

"I am so excited to play the final of a Grand Slam against one of the best ever players. It's the perfect final and I am so happy," she said.

"I grew up on clay so for Spain and me this is just amazing.

"Serena is a very powerful player and I just tried to fight as hard as I can."

For Williams it was a second straight loss in a Grand Slam final and it wrecked her hopes once again of winning a 22nd Grand Slam title to draw level with Steffi Graf for most wins in the Open era, since 1968.

She will now turn her focus on Wimbledon where she will be the defending champion and a six-time former winner.

"Congratulations to Garbine, she played really well today," said Williams, who confirmed that she had been slightly troubled by an adductor problem.

"I could have served better, made a lot of errors on return, but I did try hard out there."

The players took contrasting routes to get to the final.

Fourth seed Muguruza breezed through, losing just the one set, in her opening match, while Williams struggled past the quarter- and semi-finals amid talk of an injury or illness.

But with weather conditions improving after one of the rainiest Roland Garros tournaments on record, it was a different, more focussed Williams that got the final underway with a love service game.

Muguruza replied in kind as two of the biggest and best servers in the women's game went head to head.

The 22-year-old Spaniard had to battle hard to level at 2-2, saving two break points along the way, but she then grabbed the first break of the final thanks to a loose game from the American culminating in a double fault.

Muguruza, who lost to Williams in the Wimbledon final last year, moved 4-2 ahead, but she lost her range two games later to allow the American to level the score.

The tall Spaniard was matching Williams for power and when the title-holder opened the 11th game with a double fault she seized the opportunity to apply some added pressure on her opponent.

Her tactics paid off with Williams failing to cope with a series of explosive baseline groundstrokes.

Muguruza's second break of the final allowed her to serve for the set and she duly managed that staving off two break-back points along the way.

A top quality first set had taken 56 minutes with Muguruza winning 41 points to 40 for Williams underlining the closeness of the contest.