World number one Sinner swept aside Musetti 6-1, 6-4, 6-2 in the first all-Italian men's quarter-final in Grand Slam history.
Defending champion Carlos Alcaraz composed himself after a slow start before charging into back-to-back French Open finals when eighth seed Lorenzo Musetti retired with a left thigh injury while trailing 4-6 7-6(3) 6-0 2-0 on Friday.
Carlos Alcaraz won his first Monte Carlo Masters title on Sunday with a 3-6, 6-1, 6-0 victory over the Italian Lorenzo Musetti.
Federer described the absence of one-handers in the top 10 as a "dagger" to the sport.
Now Musetti has another special day on his agenda -- facing Djokovic in Friday's semi-finals at the All England Club.
The emotions of lifting his maiden Tour-level trophy will be hard to forget for 20-year-old Italian Lorenzo Musetti, who overcame disrupted preparations and survived a rollercoaster ride at the ATP 500 event in Hamburg.
