Despite missing star winger Lamine Yamal, Barca recorded their fourth consecutive victory across all competitions without the teenager.
Hansi Flick's Barca are a step away from reaching the semi-finals for the first time since 2019 and extended their unbeaten run to 23 matches.
Polish international Lewandowski, 35, was on the receiving end of a crunching tackle from Porto's David Carmo in the first half of Barca's 1-0 win on Wednesday.
The coach, who signed a new deal until 2025 this week, celebrated with his 50th victory in La Liga, as Robert Lewandowski's brace and Joao Cancelo's late winner helped his team triumph despite entering the final 10 minutes two goals behind.
While the Catalan side took another step towards their 27th LaLiga title, Real will look for a win against Valladolid on Sunday to keep their slim hopes alive
Two of the most intimidating forwards in world football, Argentina's 35-year-old Lionel Messi and Poland's 34-year-old Robert Lewandowski, line up against each other on Wednesday with a last 16 place at stake in the World Cup.
