Casemiro is the latest absence for Brazil, following injuries to Man City keeper Ederson, Arsenal striker Gabriel Martinelli and Paris St Germain defender Marquinhos, ahead of a match at Wembley on March 23 and one in Madrid's Santiago Bernabeu three days later.
The 23-year-old has been out since suffering a hamstring injury against Celta Vigo on August 25 but has recovered quicker than expected.