The first leg at the San Siro ended in a 2-2 draw and Inter must either win or get a higher-scoring draw at the Mestella stadium to reach the quarter-finals.

Adriano pulled his left hamstring in Wednesday's 1-1 Serie A draw against Udinese, forcing him to miss Saturday's 2-1 victory at Livorno which saw Inter stretch their lead at the top of the table to 16 points.

Hernan Crespo, suspended for the Livorno match, is likely to partner Zlatan Ibrahimovic in attack if Adriano fails to prove his fitness.

Inter's dynamic French midfielder Patrick Vieira has already been ruled out due to a torn right hamstring, while Argentine midfielder Esteban Cambiasso is struggling to recover from the right leg injury he picked up in the first leg against the Spaniards.

Olivier Dacourt is expected to replace Vieira as the holding midfielder, flanked by Dejan Stankovic on the right and Javier Zanetti on the left.

Julio Cesar is almost certain to keep goal, protected by a back four of Maicon, Ivan Cordoba, Marco Materazzi and Nicolas Burdisso.