Captain Paolo Maldini, Alessandro Costacurta, Cafu, Kakha Kaladze and Marek Jankulovski are all carrying knocks, while Serginho and Alessandro Nesta are long-term injury victims.

Meanwhile Massimo Oddo is serving a one-match ban after being sent off in Sunday's 1-0 win against Sampdoria.

"We have an emergency at the back, but we mustn't let it get us down," said AC Milan coach Carlo Ancelotti on Tuesday.

"Morale is good and confidence is high. Paradoxically these problems can give you added motivation."

Daniele Bonera, Giuseppe Favalli and Dario Simic are the only three defenders with first-team experience available for the trip to Sicily.

The match is vital in the race for Champions League places next season.

Palermo are third on 44 points, eight clear of AC Milan who have played a game less than the Sicilians.